منابع مشابه
Stem Cells and Cardiac Repair
Discovery of tissue specific stem cells capable of forming cardiac cell types has revolutionized cardiac medicine. Not long ago, cardiac tissue regeneration was considered an impossible task. The last ten years however has seen an explosion of cell based therapeutic approaches stimulating cardiac regeneration and in the process augmenting function in the heart following injury. Encouraging prec...
متن کاملMesenchymal stem cells and cardiac repair
Accumulating clinical and experimental evidence indicates that mesenchymal stem cells (MSCs) are promising cell types in the treatment of cardiac dysfunction. They may trigger production of reparative growth factors, replace damaged cells and create an environment that favours endogenous cardiac repair. However, identifying mechanisms which regulate the role of MSCs in cardiac repair is still a...
متن کاملStem cells for cardiac repair: an introduction
Cardiovascular disease is a major cause of morbidity and mortality throughout the world. Most cardiovascular diseases, such as ischemic heart disease and cardiomyopathy, are associated with loss of functional cardiomyocytes. Unfortunately, the heart has a limited regenerative capacity and is not able to replace these cardiomyocytes once lost. In recent years, stem cells have been put forward as...
متن کاملStem cells and cardiac repair: alternative and multifactorial approaches
Severe myocardial infarction can lead to ventricular remodelling and progressive contractile dysfunction with inability of the heart to maintain perfusion to vital organs. Pharmacological and surgical interventions can only alleviate symptoms or retard further disease progression. However, these interventions fail to regenerate dead myocardium. Stem cells have the potential to replace or repair...
متن کاملStem Cells for Cardiac Repair: Status, Mechanisms, and New Strategies
Faced with the end stage of heart disease, the current treatments only slow worsening of heart failure. Stem cells have the potential of self-renewal and differentiation. It is expected to replace and repair damaged myocardium. But many clinical trials have shown that the stem cell therapy of heart failure is modest or not effective. The possible causes for the limited effects of stem cell in c...
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ژورنال
عنوان ژورنال: Stem Cells International
سال: 2015
ISSN: 1687-966X,1687-9678
DOI: 10.1155/2015/153627